- Systemic fungal infection such as Aspergillus spp, Candida spp and/or Cryptococcus spp:
- IV 3-5 mg/kg/dose every 24 hours
- IV 3-5 mg/kg/dose every 24 hours
- Febrile neutropenia in empiric therapy for presumed fungal infection:
- IV 3-5 mg/kg/dose every 24 hours
- Cryptococcal meningitis:
- IV 6mg/kg/dose every 24 hours *11-21 days
- IV 6mg/kg/dose every 24 hours *11-21 days
- Visceral leishmaniasis:
- Immunocompetent patients: IV 3mg/kg/dose every 24 hours on days 1-5, 14, 21
- Immunocompromised patients: IV 4mg/kg/dose every 24 hours on days 1-5, 10, 17, 24, 31, 38
Injection: 50mg
It should be injected slowly over 2 hours
Polyene antifungal
It acts by binding to sterols in fungal cell membrane leading to alterations in cell permeability and cell death
- Rigors
- Hypokalemia
- Anemia
- Nausea
- Vomiting
- Hypomagnesemia
- Elevated BUN/ Cr
- Dyspnea
- Diarrhea
- Rash
- Headache
- Fever
- Tachycardia
- Increased LFTs
- Hypotension
- Chest pain
- Abdominal pain
- Flushing
- Urticaria
- Hypersensitivity to class/components
- None remarkable
Drug Status
| Availability | Prescription only |
| Pregnancy | Category B; Can be used |
| Breastfeeding | Can be used |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Amphizone | 50mg | Injection | 1’s | Gufic Stridden | Europa Healthcare |
| Ambilip | 50mg | Injection | 1’s | United Biotech | Salama Pharma |
| Amphonex | 50mg | Injection | 1’s | Bharat Serum | Nairobi Enterprises |
| Amphot | 50mg | Injection | 1’s | Lyka Labs | Harley’s Ltd |
| Amphotericin B | 50mg | Injection | 1’s | Asence Pharma | Medisel Kenya |
| Amphotericin B | 50mg | Injection | 1’s | Dawa Ltd | Dawa Ltd |
| Amphotret | 50mg | Injection | 1’s | Bharat Serums | Nairobi Enterprises |
| Lipholyn | 100mg | Injection | 1’s | Lyka Labs | Harley’s Ltd |