Glimepiride/ Metformin/ Pioglitazone

Tablet:

• 2mg/ 500mg/ 15mg
• 4mg/ 500mg/ 15mg

• Take with meals to minimise GI side effects from metformin and reduce the risk of hypoglycemia.
• Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis (from metformin).

• Glimepiride (Sulfonylurea): It stimulates pancreatic beta cells to release insulin, lowering blood glucose levels.

• Metformin (Biguanide): It decreases hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity.

• Pioglitazone (Thiazolidinedione): It enhances insulin sensitivity by activating PPARγ receptors in fat and muscle tissue, increasing glucose uptake.

• Hypoglycemia
• Dizziness
• Headache
• GI disturbances (nausea, diarrhoea)
• Metallic taste
• Risk of lactic acidosis
• Edema
• Weight gain

• Severe renal impairment
• Heart failure (NYHA Class III/IV)
• Known hypersensitivity to components
• Diabetic ketoacidosis
• Type 1 diabetes mellitus

• Gemfibrozil
• Alcohol