• Invasive intestinal amebiasis:
    • Adults: PO 800mg TDS *5-10 days
    • 7-10 yrs: PO 400mg TDS * 5/7
    • 3-7 yrs: 200mg QID *5/7
    • 1-3yrs: 200mg TDS*5/7
  • Eradication of cysts in symptomless carriers:
    • PO 400mg-800mg TDS *5-10 days
  • Prophylaxis of post-operative infections:
    • Adults & >12 yrs: PO 1g TDS day prior to surgery OR IV 500mg*1, 60 min prior to surgery
    • <12yrs: PO 20-30mg/kg (maximum 500mg) single dose, 1-2 hrs before surgery
  • Treatment of urogenital trichomoniasis:
    • Adults & >10 yrs: PO 200mg TDS *1/52 OR PO 400mg BD *5-7 days OR PO 2g as a single dose.
      • Sexual partners should receive similar concurrent treatment
    • 7 -10 yrs: PO 100mg TDs*1/52
    • 3-7 yrs: PO 100mg BD *1/52
    • 1-3 yrs: PO 50mg TDS *1/52
  • Bacterial vaginosis:
    • PO 400mg BD *5-7 days OR PO 2g*1
  • Pelvic Inflammatory Disease:
    • PO 400mg BD OR IV 500mg BD *14/7
  • Bacterial vaginosis:
    • PO 400mg BD *1/52 OR 2g *1
    • PO 250mg TDS *1/52 in pregnant patients
  • Giardiasis:
    • Adults: PO 2g OD *3/7 OR PO 400mg TDS *5/7
    • 7-10 yrs: PO 1g *3/7
    • 3-7 yrs: PO 600-800mg OD *3/7
    • 1-3 yrs: PO 500mg OD *3/7
  • Acute ulcerative gingivitis/ dental infections:
    • Adults: PO 400mg TDS *3/7
    • 10-18 yrs: PO 200mg-250mg TDS * 3-7 days.
    • 7-10 yrs: PO 100mg TDS * 3-7 days.
    • 3-7 yrs: PO 100mg BD * 3-7 days
    • 1-3 yrs: PO 50mg TDS * 3-7 days.
  • Leg ulcers/pressure sores:
    • Adults: PO 400mg TDS *1/52
    • 12 -18 yrs: PO 400mg BD* 14/7
  • Amebiasis:
    • Adults: PO 800mg TDS*5/7
    • 7-10yrs: PO 400mg TDS*5/7
    • 3-7 yrs: PO 200mg QID *5/7
    • 1-3 yrs: PO 200mg TDS*5/7
  • Tablet:
    • 200mg
    • 400mg
  • Suspension:
    • 200mg/5mL
  • Injection:
    • 0.5% w/v
  • Avoid alcohol while taking medication and for at least three days after discontinuation.
  • To prevent stomach upset, take this medication with food or a full glass of water or milk.

Nitroimidazole

It acts by inhibiting nucleic acid synthesis by disrupting DNA and causing strand breakage; amoebicidal, bactericidal and trichomonacidal. Active against: Balantidium coli, Blastocystis hominis, Entamoeba histolytica, Giardia lambia and Trichomonas vaginalis. Also active against Bacteroides and Clostridium spp.

  • GI disturbances especially nausea
  • Metallic taste
  • Headache
  • Anorexia
  • Vomiting
  • Diarrhea
  • Dry mouth
  • Furred tongue
  • Darkened urine
  • Transient fall in BP
  • Bone marrow depression
  • Vertigo
  • Dizziness
  • Depression
  • Insomnia.
  • Pseudomembranous colitis
  • Hypersensitive reactions
  • Concurrent antihypertensive therapy
  • Alcohol
  • Disulfiram
  • Lopinavir/ritonavir
  • Lithium

                              Drug Status

Availability Prescription or OTC by Pharmacist
Pregnancy Category B2; Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Abagyl 0.5% w/v Injection 100mL Abacus Pharma Abacus Pharma
Amebazole 200mg/5mL Suspension 60mL, 100mL Sphinx Pharma Sphinx Pharma
Amebazole 400mg Tablet 100’s Sphinx Pharma Sphinx Pharma
Amebazole 200mg Tablet 250’s Sphinx Pharma Sphinx Pharma
Amebil 200mg/5mL Suspension 60mL, 100mL Njimia Ltd Njimia Ltd
Amizole 200mg/5mL Suspension 60mL, 100mL Biopharma Ltd Biopharma Ltd
Amizole 200mg Tablet 100’s, 1000’s Biopharma Ltd Biopharma Ltd
Amizole 400mg Tablet 100’s Biopharma Ltd Biopharma Ltd
Axagyl 0.5% w/v Injection 100mL Axa Parenterals Axa Parenterals
Dangyl 200mg Tablet 100’s Dinlas Pharma Dinlas Pharma
Dangyl 200mg/5mL Suspension 60mL, 100mL Dinlas Pharma Dinlas Pharma
Eflaron 400mg Tablet 100’s Dawa Ltd Dawa Ltd
Eflaron 200mg/5mL Suspension 60mL, 100mL Dawa Ltd Dawa Ltd
Eflaron 200mg Tablet 100’s Dawa Ltd Dawa Ltd
Elogyl 200mg Tablet 100’s Elys Chemicals Elys Chemicals
Elogyl 400mg Tablet 100’s Elys Chemicals Elys Chemicals
Elogyl 200mg/5mL Suspension 60mL, 100mL Elys Chemicals Elys Chemicals
Filmet 200mg/5mL Suspension 60mL Beximco Pharma Madawa Pharma
Flagimed 200mg/5mL Suspension 60mL, 100mL Medivet Products Medivet Products
Flagyl 200mg/5mL Suspension 100mL Sanofi-Aventis Ressourcethica Kenya
Flagyl 400mg Tablet 100’s Sanofi-Aventis Ressourcethica Kenya
Flagyl 0.5% w/v Injection 100mL Sanofi-Aventis Ressourcethica Kenya
Medzol 400mg Tablet 100’s, 400’s Careplus Ltd Careplus Ltd
Megyl 400mg Tablet 100’s Regal Pharma Regal Pharma
Megyl 200mg Tablet 100’s Regal Pharma Regal Pharma
Megyl 200mg per 5mL Suspension 100mL Regal Pharma Regal Pharma
Metris 0.5% w/v Injection 100mL Claris Otsuka Reddys Pharma
Metris 0.5% w/v Injection 100mL Claris Otsuka Reddys Pharma
Metrogyl 200mg Tablet 100’s Unique Pharma Harley’s Ltd
Metrogyl 0.5% w/v Injection 100mL Unique Pharma Harley’s Ltd
Metronidazole 0.5% w/v Injection 100mL Abaris Healthcare Unisel Ltd
Metronidazole 0.5% w/v Injection 100mL Tasa Pharma Tasa Pharma
Metronidazole 0.5% w/v Injection 100mL Amanta Healthcare C/O Surgilinks Surgilinks Ltd
Metrowin 200mg Tablet 1000’s Medisel Kenya Medisel Kenya
Metrozol 400mg Tablet 100’s Cosmos Ltd Cosmos Ltd
Metrozol 400mg Tablet 100’s Cosmos Ltd Cosmos Ltd
Metzole 0.5% w/v Injection 100mL Global Pharma Medox Pharma
Mindazole 0.5% w/v Injection 100mL Kilitch Drugs Nedah Pharma
Nelzole 200mg/5mL Suspension 60mL Universal Corporation Universal Corporation
Nirmet 0.5% w/v Injection 100mL Aculife Healthcare Crown Healthcare
Shelgyl-200 200mg Tablet 1000’s Shelys Pharma Beta Healthcare
Trichazole 0.5% w/v Injection 100mL Fresenius Kabi Surgipharm Ltd
Trichogyl 0.5% w/v Injection 100mL Til Healthcare Harley’s Ltd
Tricozole 200mg Tablet 100’s Laboratory & Allied Laboratory & Allied
Tricozole 400mg Tablet 100’s Laboratory & Allied Laboratory & Allied
Tricozole 200mg/5mL Suspension 60mL, 100mL Laboratory & Allied Laboratory & Allied
Trogyl 200mg Tablet 100’s Biodeal Labs Biodeal Labs
Trogyl 400mg Tablet 100’s Biodeal Labs Biodeal Labs
Trogyl 200mg/5mL Suspension 60mL, 100mL Biodeal Labs Biodeal Labs
Troz 0.5% w/v Injection 100mL Zawadi Healthcare Zawadi Healthcare